Acute migraine attacks:
- Adult: 200 mg when 1st symptoms appear may be repeated once after 1-2 hr.
- Renal impairment: Dose adjustments may be needed. Severe: Avoid.
Mild to moderate pain:
Preclinical safety data
- Children: A pediatric dosage regimen has not yet been established.
- Adult: 100-200 mg tid.
- Renal impairment: Dose adjustments may be needed. Severe: Avoid. It should be taken with food. Take water/ or immediately after meals.
: The therapeutic index for Tolfenamic acid is high, and gastrointestinal ulceration and kidney changes have only been seen with oral doses approximately 6-10 times the maximum therapeutic dose recommended for tolfenamic acid. Special Precautions
: Asthma, bronchospasm, bleeding disorders, cardiovascular diseases, history of peptic ulceration, hypertension, patients with infections, liver, cardiac, or renal function impairment. Increase water intake or dose reduction to reduce dysuria. CHF; elderly; lactation.